2005 US Frontiers of Science Symposium

Addiction: An Evolutionary Perspective On Understanding Individual Differences in Risk and Resilience

Allyson J. Bennett, Wake Forest University School of Medicine

 1. Introduction

 2. What specific factors contribute to individual differences in resilience vs vulnerability, and how does this happen?

 3. Conceptual Model: Probabilistic Epigenesis

 4. Risk Pathways: Individual

 5. Primate phylogeny

 6. Rhesus monkey mother & infant

 7. Rhesus monkey nursing

 8. Rhesus monkey and offspring

 9. Adult male rhesus monkey

10. Rhesus monkey

11. Rhesus monkeys

12. Translational Prevention & Treatment Research

13. Translational research: Risk factors for alcoholism and substance abuse identified in human studies then studied in animal models

14. Hypothesized Relationship Between One Aspect of Personality and Risk for Substance Abuse and Alcoholism

15. Cross-Species Temperament Measurement

16. Black Box Test

17. Ethanol Self-Administration Procedure

18. Long-term Heavier Drinkers Are Faster to Approach and Touch Novel Objects

19. Fast Time to Touch Novel Object Predicts Excessive Alcohol Consumption over 10 months

20. Fast Time to Touch Novel Object & Faster Consumption of  a Fixed-Dose of Alcohol

21. Risk Pathways to Addiction

22. Serotonin (5HT) and Dopamine

23. Serotonin (5HT)

24. Serotonin is Related to Sensation-Seeking

25. Risk Pathways to Addiction

26. Human and Macaque 5HTTLPR Polymorphism

27. Gene x Environment Interplay

28. Early Controlled Environment: Nursery

29. Interactive Effect of Genotype & Early Experience on Central Serotonin Function

30. Interactive Effect of Genotype & Socioeconomic Status on Central Serotonin Function in Humans

31. Effect of 5httlpr Genotype on  Binge-drinking in College Students

32. Short Latency to Touch Novel Object is Associated with Genotype

33. Natural Selection

34. Environmental Cues

35. Hypothesis for Relationship Between Early Developmental Environment and One Aspect of the Risk Pathway

36. Nursery-reared Monkeys Are Faster to Approach and Touch Novel Objects

37. Nursery-reared Monkeys Consume Alcohol More Quickly in Initial Sessions

38. Preliminary Evidence: Nursery-reared Monkeys Consume More Alcohol In 12-months of 22hr Sessions

39. Risk Pathways: Individual

40. Acknowledgements
 
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