2003 US Frontiers of Science Symposium

2005 US Frontiers of Science Symposium

Why Our Brains Get Addicted: Insights from Neurobiology

Regina Carelli, The University of North Carolina, Chapel Hill

1. Introduction

2. Brain “Reward” Circuit

3. Similar Brain “Reward” Circuit in Rats

4. Why Our Brains Get Addicted

5. Brain cells (neurons) communicate with each other via chemical (e.g. dopamine) and electrical signaling

6. Electrophysiological Recordings during Behavior

7. Comparison of Nucleus Accumbens Cell Firing during Cocaine Self-Administration vs. Water Reinforcement in Rats

8. Initial Investigation

9. Initial Investigation

10. Initial Investigation

11. Early Interpretation

12. Objective / Method

13. Multiple Schedule: Water and Cocaine

15. Multiple Schedule: Water and Cocaine

16. Major Finding

17. Major Finding

18. Multiple Schedule: Water and Food Reinforcement

19. Water and Food

22. Findings Indicate

24. Question / Recent Finding

25. Objective / Method

26. Session 1: Water Selective Neuron

27. Results / Findings Indicate

28. Implications for Evolution of Addiction

29. Dopamine during cocaine self-administration

30. Dopamine relative to cocaine cues

31. Dopamine during responding for natural reward

33. Acknowledgements

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