2005 US Frontiers of Science Symposium

2005 US Frontiers of Science Symposium

Design Principles of the Brain

Leah Krubitzer, University of California, Davis

1. Introduction

2. How does evolution build a complex brain?

5. Problem: Evolution of mammalian neocortex cannot be studied directly

8. Modifications to the Neocortec

9. Addition of modules and changes in the number of cortical fields

15. Changes in the size of the cortical sheet

16. A change in the relative size of the neocortex is associated with an increase in the number of cortical fields

17. How does a disproportionate increase in cortical sheet size contribute to cortical field formation?

21. Cortical Enlargement: Preliminary Data

22. Preliminary Data

23. Alterations in cortical domain, cortical field size,and internal organization

25. Early Bilateral enucleation experiments

27. Conclusions

28. How do activity dependent alterations in the phenotype that are context dependent ultimately get incorporated into the genome?

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Copyright © 2005. National Academy of Sciences. All rights reserved.